What is HLA- B27?
Human Leukocyte antigen B27 (HLA- B27) belongs to the group of cell surface glycoproteins which are expressed on most nucleated human cells and platelets. It is a major histocompatibility complex (MHC) class I molecule. The presence of HLA-B27 is strongly associated with ankylosing spondylitis and some inflammatory disorders like Reiter’s syndrome, inflammatory bowel syndrome, etc. HLA-B27 test is generally advised to patients suffering from joint pain where ankylosing spondylitis is suspected. A positive test result indicates higher chances of developing this disease.
Rheumatologist, General physician, General Medicine, Immunologist